diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseAncillaryManageService.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseAncillaryManageService.java
index c2175efe..f4693614 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseAncillaryManageService.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseAncillaryManageService.java
@@ -16,4 +16,7 @@ public interface DiseaseAncillaryManageService {
     boolean updateAncillary(DiseaseAncillary diseaseAncillary);
 
 
+    boolean deleteByDiseaseId(String diseaseId);
+
+
 }
diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseasePhysicalManageService.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseasePhysicalManageService.java
index 0d6346ae..765d5250 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseasePhysicalManageService.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseasePhysicalManageService.java
@@ -14,4 +14,6 @@ public interface DiseasePhysicalManageService {
     boolean deletePhysical(String id);
 
     boolean updatePhysical(DiseasePhysical diseasePhysical);
+
+    boolean deleteByDiseaseId(String diseaseId);
 }
diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseQuestionManageService.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseQuestionManageService.java
index 416731f4..1385dd54 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseQuestionManageService.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseQuestionManageService.java
@@ -12,4 +12,6 @@ public interface DiseaseQuestionManageService {
     void batchSaveQuestion(List<DiseaseQuestion> diseaseQuestionList);
 
     boolean deleteDiseaseQuestion(String id);
+
+    boolean deleteByDiseaseId(String diseaseId);
 }
diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseTreatmentPlanManageService.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseTreatmentPlanManageService.java
index 0a1d9c8d..3ebc5ecc 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseTreatmentPlanManageService.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/DiseaseTreatmentPlanManageService.java
@@ -15,4 +15,6 @@ public interface DiseaseTreatmentPlanManageService {
     void batchSaveTreatmentPlan(List<DiseaseTreatmentPlan> diseaseTreatmentPlanList);
 
     boolean deleteDiseaseTreatmentPlan(String id);
+
+    boolean deleteByDiseaseId(String diseaseId);
 }
diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseAncillaryManageServiceImpl.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseAncillaryManageServiceImpl.java
index d0b59ddd..a0308c9c 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseAncillaryManageServiceImpl.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseAncillaryManageServiceImpl.java
@@ -3,6 +3,8 @@ package com.supervision.manage.service.impl;
 import cn.hutool.core.collection.CollUtil;
 import cn.hutool.core.lang.Assert;
 import cn.hutool.core.util.StrUtil;
+import com.baomidou.mybatisplus.core.conditions.query.QueryWrapper;
+import com.baomidou.mybatisplus.extension.conditions.update.LambdaUpdateChainWrapper;
 import com.supervision.manage.service.DiseaseAncillaryManageService;
 import com.supervision.model.DiseaseAncillary;
 import com.supervision.service.DiseaseAncillaryService;
@@ -54,6 +56,13 @@ public class DiseaseAncillaryManageServiceImpl implements DiseaseAncillaryManage
         return diseaseAncillaryService.updateById(diseaseAncillary);
     }
 
+    @Override
+    public boolean deleteByDiseaseId(String diseaseId) {
+        Assert.notEmpty(diseaseId,"疾病id不能为空");
+
+        return diseaseAncillaryService.lambdaUpdate().eq(DiseaseAncillary::getDiseaseId, diseaseId).remove();
+    }
+
 
     private void assertDiseaseAncillary(DiseaseAncillary diseaseAncillary){
 
diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseManageServiceImpl.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseManageServiceImpl.java
index f8a39b15..8bb835a4 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseManageServiceImpl.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseManageServiceImpl.java
@@ -6,13 +6,15 @@ import cn.hutool.core.util.StrUtil;
 import com.baomidou.mybatisplus.extension.conditions.query.LambdaQueryChainWrapper;
 import com.baomidou.mybatisplus.extension.plugins.pagination.Page;
 import com.supervision.exception.BusinessException;
-import com.supervision.manage.service.DiseaseManageService;
+import com.supervision.manage.service.*;
 import com.supervision.model.Disease;
 import com.supervision.model.DiseaseAncillary;
+import com.supervision.service.DiseaseAncillaryService;
 import com.supervision.service.DiseaseService;
 import com.supervision.vo.manage.DiseaseVo;
 import lombok.RequiredArgsConstructor;
 import org.springframework.stereotype.Service;
+import org.springframework.transaction.annotation.Transactional;
 
 import java.util.List;
 import java.util.Objects;
@@ -21,6 +23,14 @@ import java.util.Objects;
 public class DiseaseManageServiceImpl implements DiseaseManageService {
 
     private final DiseaseService diseaseService;
+
+    private final DiseaseAncillaryManageService diseaseAncillaryManageService;
+
+    private final DiseasePhysicalManageService diseasePhysicalManageService;
+
+    private final DiseaseQuestionManageService diseaseQuestionManageService;
+
+    private final DiseaseTreatmentPlanManageService diseaseTreatmentPlanManageService;
     @Override
     public Disease saveDisease(Disease disease) {
 
@@ -43,11 +53,25 @@ public class DiseaseManageServiceImpl implements DiseaseManageService {
     }
 
     @Override
+    @Transactional
     public boolean deleteDisease(String id) {
 
-        //todo: 应该删除其他关联信息
+        // 1. 删除疾病信息
+        diseaseService.removeById(id);
+
+        // 2. 删除疾病辅助检查信息
+        diseaseAncillaryManageService.deleteByDiseaseId(id);
+
+        // 3. 删除疾病体格检查信息
+        diseasePhysicalManageService.deleteByDiseaseId(id);
+
+        //4. 删除疾病问题信息
+        diseaseQuestionManageService.deleteByDiseaseId(id);
+
+        // 5. 删除疾病处置计划信息
+        diseaseTreatmentPlanManageService.deleteByDiseaseId(id);
 
-        return diseaseService.removeById(id);
+        return true;
     }
 
     @Override
diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseasePhysicalManageServiceImpl.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseasePhysicalManageServiceImpl.java
index 3e93e1f5..9e7805c3 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseasePhysicalManageServiceImpl.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseasePhysicalManageServiceImpl.java
@@ -50,6 +50,13 @@ public class DiseasePhysicalManageServiceImpl implements DiseasePhysicalManageSe
         return diseasePhysicalService.updateById(diseasePhysical);
     }
 
+    @Override
+    public boolean deleteByDiseaseId(String diseaseId) {
+
+        Assert.notEmpty(diseaseId,"疾病id不能为空");
+        return diseasePhysicalService.lambdaUpdate().eq(DiseasePhysical::getDiseaseId,diseaseId).remove();
+    }
+
 
     private void assertDiseasePhysical(DiseasePhysical diseasePhysical){
 
diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseQuestionManageServiceImpl.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseQuestionManageServiceImpl.java
index 21942ca0..5abcc71f 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseQuestionManageServiceImpl.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseQuestionManageServiceImpl.java
@@ -4,6 +4,7 @@ import cn.hutool.core.collection.CollectionUtil;
 import cn.hutool.core.lang.Assert;
 import cn.hutool.core.util.StrUtil;
 import com.baomidou.mybatisplus.extension.conditions.query.LambdaQueryChainWrapper;
+import com.supervision.manage.service.DiseaseAncillaryManageService;
 import com.supervision.manage.service.DiseaseQuestionManageService;
 import com.supervision.model.DiseaseQuestion;
 import com.supervision.service.AskTemplateQuestionLibraryService;
@@ -47,6 +48,13 @@ public class DiseaseQuestionManageServiceImpl implements DiseaseQuestionManageSe
        return diseaseQuestionService.removeById(id);
     }
 
+    @Override
+    public boolean deleteByDiseaseId(String diseaseId) {
+        Assert.notEmpty(diseaseId,"疾病id不允许为空");
+
+        return diseaseQuestionService.lambdaUpdate().eq(DiseaseQuestion::getDiseaseId, diseaseId).remove();
+    }
+
 
     private List<DiseaseQuestion> findListByDiseaseIdAndQuestionIdGroup(List<DiseaseQuestion> diseaseQuestionList){
 
diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseTreatmentPlanManageServiceImpl.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseTreatmentPlanManageServiceImpl.java
index cd57248b..e8621b7c 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseTreatmentPlanManageServiceImpl.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseTreatmentPlanManageServiceImpl.java
@@ -5,6 +5,7 @@ import cn.hutool.core.util.StrUtil;
 import com.supervision.manage.service.DiseaseTreatmentPlanManageService;
 import com.supervision.model.ConfigTreatmentPlan;
 import com.supervision.model.DiseaseTreatmentPlan;
+import com.supervision.service.DiseaseQuestionService;
 import com.supervision.service.DiseaseTreatmentPlanService;
 import com.supervision.vo.manage.DiseaseTreatmentPlanResVo;
 import lombok.RequiredArgsConstructor;
@@ -49,6 +50,13 @@ public class DiseaseTreatmentPlanManageServiceImpl implements DiseaseTreatmentPl
         return diseaseTreatmentPlanService.removeById(id);
     }
 
+    @Override
+    public boolean deleteByDiseaseId(String diseaseId) {
+        Assert.notEmpty(diseaseId,"疾病id不能为空");
+
+        return diseaseTreatmentPlanService.lambdaUpdate().eq(DiseaseTreatmentPlan::getDiseaseId,diseaseId).remove();
+    }
+
 
     private void assertDiseaseTreatmentPlan(DiseaseTreatmentPlan diseaseTreatmentPlan){