diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/ConfigTreatmentPlanManageServiceImpl.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/ConfigTreatmentPlanManageServiceImpl.java
index 824fdaaa..f3832cab 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/ConfigTreatmentPlanManageServiceImpl.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/ConfigTreatmentPlanManageServiceImpl.java
@@ -8,7 +8,9 @@ import com.baomidou.mybatisplus.extension.plugins.pagination.Page;
 import com.supervision.manage.constant.DisposalPlanEnum;
 import com.supervision.manage.service.ConfigTreatmentPlanManageService;
 import com.supervision.model.ConfigTreatmentPlan;
+import com.supervision.model.DiseaseTreatmentPlan;
 import com.supervision.service.ConfigTreatmentPlanService;
+import com.supervision.service.DiseaseTreatmentPlanService;
 import com.supervision.vo.manage.TreatmentPlanTreeNode;
 import lombok.RequiredArgsConstructor;
 import org.springframework.stereotype.Service;
@@ -22,6 +24,8 @@ public class ConfigTreatmentPlanManageServiceImpl implements ConfigTreatmentPlan
 
     private final ConfigTreatmentPlanService configTreatmentPlanService;
 
+    private final DiseaseTreatmentPlanService diseaseTreatmentPlanService;
+
     @Override
     public List<TreatmentPlanTreeNode> queryTree(Integer disposalMethod) {
 
@@ -60,10 +64,22 @@ public class ConfigTreatmentPlanManageServiceImpl implements ConfigTreatmentPlan
     public boolean deleteTreatmentPlan(String id) {
 
         Assert.notEmpty(id,"id 不允许为空");
-
+        assertTreatmentPlanUsed(id);
         return configTreatmentPlanService.removeById(id);
     }
 
+    /**
+     * 判断处置计划是否被使用
+     * @param id 处置计划id
+     * @return true:被使用 false:未被使用
+     */
+    public void assertTreatmentPlanUsed(String id){
+        // 有没有被疾病关联
+        boolean b = diseaseTreatmentPlanService.lambdaQuery()
+                .eq(DiseaseTreatmentPlan::getTreatmentPlanId, id).count() > 0;
+        Assert.isFalse(b,"处置计划已被疾病关联，不允许删除");
+
+    }
     @Override
     public boolean updateTreatmentPlan(ConfigTreatmentPlan configDrug) {
 
diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DrugManageServiceImpl.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DrugManageServiceImpl.java
index 983eeb99..064cd773 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DrugManageServiceImpl.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DrugManageServiceImpl.java
@@ -1,13 +1,19 @@
 package com.supervision.manage.service.impl;
 
+import cn.hutool.core.collection.CollUtil;
 import cn.hutool.core.lang.Assert;
 import cn.hutool.core.util.StrUtil;
 import com.baomidou.mybatisplus.core.metadata.IPage;
 import com.baomidou.mybatisplus.extension.conditions.query.LambdaQueryChainWrapper;
 import com.baomidou.mybatisplus.extension.plugins.pagination.Page;
+import com.supervision.manage.service.ConfigTreatmentPlanManageService;
 import com.supervision.manage.service.DrugManageService;
 import com.supervision.model.ConfigDrug;
+import com.supervision.model.ConfigTreatmentPlan;
+import com.supervision.model.DiseaseTreatmentPlanDrug;
 import com.supervision.service.ConfigDrugService;
+import com.supervision.service.ConfigTreatmentPlanService;
+import com.supervision.service.DiseaseTreatmentPlanDrugService;
 import lombok.RequiredArgsConstructor;
 import org.springframework.stereotype.Service;
 
@@ -15,7 +21,9 @@ import org.springframework.stereotype.Service;
 @RequiredArgsConstructor
 public class DrugManageServiceImpl implements DrugManageService {
 
-    private final ConfigDrugService configDrugService;;
+    private final ConfigDrugService configDrugService;
+
+    private final DiseaseTreatmentPlanDrugService diseaseTreatmentPlanDrugService;
     @Override
     public ConfigDrug saveDrug(ConfigDrug configDrug) {
         Assert.notEmpty(configDrug.getDrugName(), "药品名称不能为空");
@@ -27,10 +35,18 @@ public class DrugManageServiceImpl implements DrugManageService {
     @Override
     public boolean deleteDrugById(String id) {
         Assert.notEmpty(id, "药品id不能为空");
+        assertDrugIsUsed(id);
 
         return configDrugService.removeById(id);
     }
 
+
+    public void assertDrugIsUsed(String id) {
+        boolean diseasePlanIsUsed = diseaseTreatmentPlanDrugService.lambdaQuery().eq(DiseaseTreatmentPlanDrug::getDrugId, id).count() > 0;
+        Assert.isFalse(diseasePlanIsUsed, "药品已经在疾病处置计划中使用");
+
+    }
+
     @Override
     public boolean updateDrug(ConfigDrug configDrug) {
         Assert.notEmpty(configDrug.getId(), "药品id不能为空");