diff --git a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseManageServiceImpl.java b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseManageServiceImpl.java
index 3c2de53f..3f7577b8 100644
--- a/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseManageServiceImpl.java
+++ b/virtual-patient-manage/src/main/java/com/supervision/manage/service/impl/DiseaseManageServiceImpl.java
@@ -8,7 +8,9 @@ import com.baomidou.mybatisplus.core.metadata.IPage;
 import com.supervision.exception.BusinessException;
 import com.supervision.manage.service.*;
 import com.supervision.model.Disease;
+import com.supervision.model.MedicalRec;
 import com.supervision.service.DiseaseService;
+import com.supervision.service.MedicalRecService;
 import com.supervision.util.RedisSequenceUtil;
 import com.supervision.vo.manage.DiseaseReqVo;
 import com.supervision.vo.manage.DiseaseResVo;
@@ -34,6 +36,8 @@ public class DiseaseManageServiceImpl implements DiseaseManageService {
     private final DiseaseQuestionManageService diseaseQuestionManageService;
 
     private final DiseaseTreatmentPlanManageService diseaseTreatmentPlanManageService;
+
+    private final MedicalRecService medicalRecService;
     @Override
     public Disease saveDisease(Disease disease) {
 
@@ -71,7 +75,7 @@ public class DiseaseManageServiceImpl implements DiseaseManageService {
             return true;
         }
         Assert.isFalse(disease.getDiseaseType()==0,"单一疾病不允许被删除");
-
+        assertDiseaseIsUsed(id);
         // 1. 删除疾病信息
         diseaseService.removeById(id);
 
@@ -157,4 +161,13 @@ public class DiseaseManageServiceImpl implements DiseaseManageService {
 
     }
 
+    /**
+     * 校验疾病是否被使用
+     * @param diseaseId 疾病id
+     */
+    private void assertDiseaseIsUsed(String diseaseId){
+        boolean isUsedMedicalRec = medicalRecService.lambdaQuery().eq(MedicalRec::getDiseaseId, diseaseId).count() > 0;
+        Assert.isFalse(isUsedMedicalRec,"疾病已经关联病例，不允许删除");
+    }
+
 }